Recently, an article published in American Journal of topography found for the first time that the success rate of corneal transplantation can be improved by injecting neuropeptide (VIP) into the eyes of mice. VIP also has other advantages. Inflow can accelerate wound healing, protect corneal endothelial cells and improve the cleanliness of cornea transplantation. If the treatment can be approved, it will help to solve the problems of many patients with corneal diseases.
In this study, the authors examined the effect of VIP on corneal tissue in cell culture. And at the living level. VIP is a kind of neuropeptides containing 28 amino acids. It is believed that VIP has immunoregulatory activity and can protect multiple organ systems. In addition, the authors found a variety of functions of VIP, including its ability to accelerate wound healing. When corneal endothelial cells are exposed to apoptosis promoting environment, VIP can play a dose-dependent protective effect.
In living mice, the author first performed keratoplasty and VIP treatment. The results showed that compared with the control group, the vision of mice treated with VIP was clearer, and the thickness of corneal endothelial cells in the treatment group was significantly higher than that in the control group.
At present, one of the most common types of operations in the medical field is to repair the visual impairment caused by corneal failure. The authors believe their new findings will help improve the outcome of the operation. (Biovalley Bioon.com )
Source of information: injection of vasoactive internal fit into the eye improvements nuclear transport survival
Original source: "vasoactive internal peptide promotes nuclear allograft survival," American Journal of Philosophy (2018). Doi: 10.1016/j.ajpath.2018.05.010