Participating in the research activities of the International Symposium on cell therapy (the 11th session) in 2020

May 13, 2020 / BIOON/ --High calorie and high-energy foods are getting more and more energy sources in modern society. Recently, in a research report published in the international journal Neuron, scientists from the Max Planck Institute and other institutions found that special types of nerve cells in the mouse brain can promote the intake of high-fat foods. If the so-called pain sensitive peptide in the mouse hypothalamus When neurons are activated, mice eat more high-fat food.

Since 1980s, the incidence rate of obesity and obesity related diseases (diabetes and cardiovascular diseases) has been increasing in the world. Researchers have used mice to analyze which neurons control excessive intake of high calorie and high-energy foods. For this purpose, researchers fed mice a high-fat diet and then closely monitored them. Researcher Alexander jais said that just three days of high-fat diet was enough to detect the activity of pain sensitive peptide neurons in specific areas of the mouse brain.

Later, in a series of experiments, the researchers selectively removed the pain sensitive peptide neurons from the arcuate nucleus of the mouse hypothalamus, so these mice would not take excessive high-fat diet, and their intake of normal food would not be affected. The pain sensitive peptide neurons can specifically control the body's intake of high-fat food; the researchers genetically modified the mice Light is used to control the activity of pain sensitive peptide neurons in the hypothalamus. The activation of these brain cells will lead to excessive food intake of animals, while the activation of pain sensitive peptide neurons will inhibit the activity of specific neurons regulating the sense of satiety of the body, resulting in excessive food intake of mice.

The intake of high calorie food will interfere with the energy balance of the body and increase the intake of calories. Nowadays, people are always surrounded by cheap, delicious and high-energy food. The brain of the body will operate in a way that we like these food very much. However, researchers don't know why some people only consume the amount of food they need, while some people are not The activity of peptide neurons may be an important clue to solve this mystery. Its activation will promote the body to eat too much food, which may make the pain sensitive peptide neurons become a special target to help develop new measures to prevent and treat obesity.

Finally, researcher jais said that the current prevalence of covid-19 reminds us that we need to pay close attention to the occurrence of obesity and its related metabolic diseases, such as diabetes, which are the main risk factors affecting the health of the body, so it is very important for researchers to better understand how the central nervous system controls the intake of food, especially for high calorie, high fat and High carbohydrate food intake. (Biovalley )

Original source:

Alexander Jais,Lars Paeger,Tamara Sotelo-Hitschfeld, et al. PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding, Neuron (2020). DOI: 10.1016/j.neuron.2020.03.022