In recent years, the global peptide drug market as a whole is in a rising period, with a compound growth rate of more than 12% and a market size of nearly 20 billion US dollars. According to the report released by transparency market research, the global peptide drug market is expected to reach 23.7 billion US dollars by 2020. Peptide drugs have also become one of the important directions of new drug research and development.

Peptide analogues are hot spots in research and development. Polypeptides usually refer to peptide chains composed of no more than 50 amino acids, which are between small molecular drugs (molecular weight < 500) and protein drugs (molecular weight > 5000). Because peptides are involved in many physiological functions as signaling molecules in the body, peptide drugs often act as alternative therapy to compensate for the lack of endogenous peptide hormones.

Peptide drugs have been widely recognized and widely used in clinical practice from the isolation and extraction of early automatic tissue to modern artificial synthesis.

For a long time, the number of natural peptide research and development projects is small, but the pharmaceutical industry has always been enthusiastic about the research and development of peptide analogues. In particular, the number of heterologous peptides has been increasing since 2000, which also reflects the development and changes of peptide synthesis technology.

The essence of peptide synthesis (peptide chain synthesis) is to arrange amino acid units according to the structure of natural amino acids. In order to synthesize polypeptides in a specific sequence, only directed peptide synthesis method can be used, that is, the amino or carboxyl groups that do not need to be reacted are protected with appropriate groups, and then the ligation reaction is carried out. At present, the main methods of peptide synthesis are chemical synthesis and biological synthesis. The chemical synthesis methods mainly include solid-phase synthesis and liquid-phase synthesis, and the biological synthesis methods mainly include fermentation and enzymatic hydrolysis. With the development of bioengineering technology, the genetic engineering method dominated by DNA recombination technology has also been applied to peptide synthesis.

Transferred from: China Medical Journal