Our reporter (reporter Zhang Daozheng, correspondent Liu Xiaoyan) learned from Tianjin University on October 10 that Professor Qi Wei's team from the school of chemical engineering of Tianjin University has made new progress in the preparation of peptide based targeted drug carriers by imitating viruses. Based on the targeting characteristics of natural virus, peptide sequence design, self-assembly strategy of peptide, imitating the structure and function of virus, the non pathogenic, performable membrane, and targeted delivery of gene drugs of virus like nanoparticles are prepared, which are expected to be used as "Trojan horse" to achieve "attacking virus with virus".

Virus is a kind of nanoparticle formed by the co assembly of nucleic acid and protein. Because of the unique structure of envelope protein on the surface of virus, it can target and bind with receptor protein of host cell, and realize the infection of specific cell and delivery of genetic material. Through the simulation and bionics of virus functional protein, it is expected to obtain non pathogenic, gene drug carrying, and targeted recognition of virus nanoparticles for the treatment of related diseases.

However, due to the complexity of the virus structure, how to accurately prepare the virus like particles through simple molecules, and how to effectively assemble the peptide sequence to effectively biomimetic the viral membrane penetration behavior are still full of challenges.

Professor Qiwei's team designed two kinds of functional polypeptides with cell membrane and nuclear membrane through molecular and nano bionics based on the nuclear location sequence of variable region polypeptides on HIV surface and large T antigen protein molecules of simian vacuolation virus (SV40). Through the regulation of viral peptide assembly, the researchers successfully produced virus like nanoparticles. The experimental results show that the particle can be used as a Trojan horse to carry nucleic acid gene drugs and deliver them to immune cells in a virus like transmembrane manner.

The bionic virus particles also showed good biocompatibility, biological activity and directional transport characteristics in the process of gene delivery, which can provide useful reference for targeted treatment of viral diseases. The relevant achievements were published online in the international authoritative journal of Chemistry "German Applied Chemistry" and selected as the inner cover paper. The first author of this paper is Kong Jia, Ph.D. student of enzyme engineering and technology research group, School of chemical engineering, Tianjin University. The young teacher of this group, Dr. Wang Yuefei and Professor Qiwei, are co correspondents of this paper.

In recent years, Professor Qiwei's team has taken inspiration from the life system, constructed a series of peptide self-assembly systems through sequence design or introduction of functional components, and used the research ideas of chemical engineering, interface physics and other fields for reference to strengthen the assembly process, so as to achieve the precise and controllable preparation of various peptide based assemblies such as stimulation response, chirality function, etc.; simulated the activity of natural enzyme The functional protein structure of the center and virus, etc., obtained the assembly with the characteristics of biocatalysis, target recognition, etc., to achieve material transformation and drug delivery.

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