Abstract:

Hypertension is a kind of systemic disease characterized by high arterial pressure, which can be accompanied by functional or organic changes of heart, blood vessels, brain and kidney. It can be divided into primary hypertension and secondary hypertension. There are many causes of hypertension, which can be divided into genetic and environmental aspects.

Hypertension is the most common chronic disease and the main risk factor of cardiovascular and cerebrovascular diseases. Every year, 3 million people die of cardiovascular disease in China, accounting for 40% of all deaths, which is the number one killer of Chinese residents. According to WHO standard, systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg can be diagnosed as hypertension. The systolic blood pressure was 140-159mmhg and / or diastolic blood pressure was 90-99mmhg. The systolic blood pressure of normal people increases with age, so the incidence rate of hypertension increases with age.

Long term hypertension can promote the formation and development of atherosclerosis. Coronary atherosclerosis can block or narrow the blood vessels, or cause myocardial ischemia, anoxia and deterioration due to the functional change of coronary artery. Coronary atherosclerotic heart disease is the most common type of organ disease caused by atherosclerosis, and it is also a common disease seriously endangering human health.

Antihypertensive peptide, also known as angiotensin converting enzyme inhibitory peptide, usually refers to the peptide which has the effect of regulating blood pressure by eliminating the inhibition of angiotensin converting enzyme (ACE).

Antihypertensive peptides exist widely in human body, and they are also natural bioactive peptides with blood pressure regulation. It mainly includes Pro natriuretic peptide family, calcitonin gene-related peptide (37 amino acid residues), adrenomedullin peptide (52 amino acid residues), neurodepressor peptide (13 amino acid residues), bradykinin (vasoactive 9 peptide), etc.

It has become a research hotspot in the world of science and medicine to obtain ACE inhibitory peptide by enzymatic hydrolysis of animal and plant proteins. In recent years, a large number of antihypertensive peptides have been found in protein hydrolysates of animals, plants and marine fishes. Generally, these antihypertensive peptides are short peptides with small molecular weight, generally containing only a few amino acid residues, and their molecular weight is less than 1000 daltons. These small molecular active peptides can quickly enter the blood circulation through the digestive mucosa and have the effect of reducing blood pressure.

As a new antihypertensive drug, natural antihypertensive peptide has attracted more and more attention because of its high affinity and unique advantages over synthetic antihypertensive drugs. Considering the cost of pure antihypertensive peptide, people tend to use the hydrolysate as a mixture of active short peptide after preliminary separation. Compound small molecular peptide not only has high blood pressure lowering function, but also has certain health care and nutritional value. It can prevent, control, alleviate and assist the treatment of hypertension by taking it for a long time.

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Chengdu Shengnuo Biotechnology Co., Ltd. has "Chengdu polypeptide drug engineering technology research center" in Chengdu, mainly engaged in polypeptide, polypeptide drug and beauty peptide research. Our zero defect has passed the FDA certification, and now it has become the first-class professional peptide drug and product development, technology transfer, technical service and peptide drug industry in the scale production and export of China's parks.