Different from natural protein synthesis, the direction of artificial synthesis is from C to N-terminal. The specific synthesis consists of the following cycles:

① Deprotection: columns and monomers protected by Fmoc must be deprotected with piperidine.

② Activation and crosslinking: the carboxyl group of the next amino acid is activated by an activator. The activated monomer reacts with free amino group to form peptide bond.

③ Cycle: these two steps are repeated until the synthesis is completed. The synthetic peptide is then cut from the resin and deprotected. Finally, it was precipitated, eluted and freeze-dried.

Peptide customization generally refers to a kind of service of artificial peptide synthesis. It refers to the peptide synthesis service that is processed and synthesized to meet specific needs according to different requirements of customers, such as sequence, purity, molecular weight, etc. The molecular weight of the crude product was confirmed by mass spectrometer, and then the crude product was purified by HPLC. In principle, the higher the purity, the higher the price.

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About Shengnuo

Chengdu Shengnuo Biotechnology Co., Ltd. has "Chengdu polypeptide drug engineering technology research center" in Chengdu, mainly engaged in polypeptide, polypeptide drug and beauty peptide research. Our zero defect has passed the FDA certification, and now it has become the first-class professional peptide drug and product development, technology transfer, technical service and peptide drug industry in the scale production and export of China's parks.