The novel coronavirus pneumonia epidemic is spreading throughout the country, which constantly stimulates everyone's nervous nerves. An accidental sneeze is a great enemy. As everyone knows, novel coronavirus pneumonia is currently not effective, and the main reason to defeat the virus depends on its own immunity.

For a while, the whole country shouted "strengthen immunity"

On January 30, a piece of news in people's daily not only recorded the touching deeds of medical staff who went retrograde to the front line, but also brought the immune enhancer "thymosin" into the public view.

What is thymosin?

Thymus is located in the back of human sternum, which is flat and oval. It consists of left and right lobes. It is an important central immune organ.

Thymus is the place where human immune T cells develop, differentiate and mature. It can also secrete many peptide hormones. Medical researchers have made thymopeptides from these peptide hormones. At present, there are three kinds of thymosin drugs commonly used in clinic: thymosin, thymosin and thymopentin.

Common clinical thymosin drugs

Thymosin

Main indications: chronic hepatitis B; various primary or secondary T-cell defects; some autoimmune diseases; various diseases with low cellular immune function and adjuvant treatment of tumor.

Active ingredient: a small peptide mixture with nonspecific immune effect extracted from thymus tissues of healthy calves and other animals.

Dosage form: enteric coated tablet, enteric coated capsule, powder injection, injection

Administration method: enteric coated tablets and capsules; oral, 5-30mg each time, 1-3 times a day. Powder injection, injection; subcutaneous or intramuscular injection: 10-20mg once a day; intravenous drip: 20-80mg once a day. A skin test is required before the injection type is used.

Thymic five peptide

Main indications: chronic hepatitis B (people aged 18 and over); various primary or secondary T-cell defects; some autoimmune diseases; various diseases with low cellular immune function and adjuvant treatment of tumors.

Active ingredients: peptide compounds isolated and purified from thymus, five amino acids of thymogenin Ⅱ active center.

Dosage form: powder injection and injection

Administration method: intramuscular injection, subcutaneous injection, intravenous drip, refer to the literature from Italy, 50mg dose can be used every day.

Thymus method

Main indications: vaccine enhancer for patients with chronic hepatitis B and immune impairment.

Active ingredient: it is synthesized according to thymosin α 1 naturally existing in human body, and its function is consistent with that of thymosin α 1 naturally existing in human body.

Dosage form: powder injection

Administration method: subcutaneous injection

Treatment of chronic hepatitis B: 1.6mg per injection, twice a week, 3-4 days apart each time. The treatment lasted for 6 months (52 injections), and the period could not be interrupted.

Use of viral vaccine booster: the recommended dose is 1.6mg, twice a week, 3-4 days apart each time. The course of treatment lasts for 4 weeks (8 injections). The first injection is given immediately after vaccination.

The above administration methods are recommended routinely. The instructions of different manufacturers may be different, and the instructions of manufacturers shall prevail.

Application of thymosin in antiviral

Cellular immunity is very important in anti-virus infection, and T cells play a very important role in cellular immunity. Thymosin drugs can promote the development, differentiation and maturation of T cells, so they can be used for anti-virus infection. At present, it is clear that thymopeptides can inactivate hepatitis B virus (HBV). It can help to clear the HBV infected hepatocytes and reduce the recurrence of hepatitis B. Therefore, the indications for the treatment of hepatitis B have been approved in the three thymosin drug specifications.

At present, a small number of studies have shown that thymosin drugs have some adjuvant effects on human immunodeficiency virus infection, hepatitis C virus infection and rotavirus infection. In addition, the indications in the new thymus method instructions indicate that the drug can enhance the immune response of patients with hypoimmunity to influenza vaccine.

From the novel coronavirus pneumonia and the individual immune response mechanism, the use of thymosin drugs can enhance the cellular immunity function. However, there is no clinical evidence that thymosin drugs have preventive effects on new crown pneumonia.

Is it necessary for ordinary people to use thymosin drugs to improve their immunity?

It is not significant for people with normal immune function, especially those with normal T cell level and function to take thymosin drugs. In vivo studies have shown that thymosin has no significant effect on the number of basic T cells in healthy people. From the perspective of immune regulation, the immune level of healthy people keeps a dynamic balance, and T cells can play a normal cellular immune function. Blind use of thymosin drugs may break the existing immune balance and cause immune disorders.

Reminder

In the face of the epidemic situation, we should be rational and not follow blindly. It is the most simple, economic and effective prevention method to minimize going out, avoid close contact, wear masks when going out, wash hands frequently, ventilate frequently, exercise properly and ensure sleep.

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Chengdu Shengnuo Biotechnology Co., Ltd. has "Chengdu polypeptide drug engineering technology research center" in Chengdu, mainly engaged in polypeptide, polypeptide drug and beauty peptide research. Our zero defect has passed the FDA certification, and now it has become the first-class professional peptide drug and product development, technology transfer, technical service and peptide drug industry in the scale production and export of China's parks.