Biocoupling is a chemical strategy to form a stable covalent bond between two molecules, at least one of which is a biomolecule. The field of bio coupling has a significant impact on the production of academic research, clinical diagnosis and therapeutics.

Polypeptides are a kind of important molecules in bio coupling and derivatization. Peptide drug conjugates have obvious advantages in improving the potential of drug therapy and have broad prospects in drug delivery. Both linear and cyclic peptides are considered to be transporters because they are easy to synthesize, simple in structure and low in immunogenicity.

Targeted drug delivery

Research is under way to develop new drug delivery systems for targeted drug delivery. The peptide extracted from the cell surface protein sequence has a strong binding affinity to the target cell surface receptor. The combination of peptide drug conjugates with specific ligands such as EGF and RGD Peptides can provide a solution for selective targeted drug delivery.

Description of peptide bio coupling service

Diveo provides you with a one-stop solution to meet the needs of all peptide drug bio coupling. Our custom peptide synthesis, modification and coupling services involve the chemical modification of peptides at highly specific sites. This allows drugs or bioactive molecules to be efficiently linked through a variety of coupling techniques.

Through our peptide synthesis platform, diveo provides you with the best peptide bio coupling chemical technology services in the industry. The conjugates of peptide synthesis, modification and synthesis have high purity. Every peptide drug combination is strictly monitored in the synthesis process and controlled according to our quality assurance and quality control standards.

Chemistry:

Drugs and bioactive molecules are coupled with chemical reaction groups (such as amines, mercaptans, carboxylic acids, hydroxyl groups, aldehydes and ketones), active hydrogen, photochemistry and cycloaddition reactions, zero length cross-linking, homofunctional, heterofunctional or multifunctional cross-linking chemistry, dendritic molecules and dendrites as well as cleavable reagent systems.

The chemical process of biological coupling may occur through the carbon and nitrogen ends of each polypeptide chain, the carboxyl group of aspartic acid and glutamic acid, the amino group of lysine, the guanidine group of arginine, the sulfhydryl group of cysteine, the hydroxy group of tyrosine phenol, the indole ring of tryptophan, the Thioether Group of methionine and the imidazole ring of histidine.

Material Science:

Peptides and amino acids

• amino acids: ASP, Glu, Lys, Arg, Cys, Tyr, Trp, met, his

• synthetic peptides

Drugs and bioactive molecules

Procedure:

All customized biomolecular synthesis, modification or biological conjugation services are produced under strict quality control. High performance liquid chromatography (HPLC) and mass spectrometry (MS) were performed in each development cycle. The final target coupling compound must first be separated from the excess or unreacted reagents. In many cases, simple dialysis is enough to remove unreacted reagents from the reaction solution. HPLC can also be used to remove redundant reagents or to separate and characterize cross-linked products. The target molecules can be further characterized by biochemical or biophysical techniques. QC (quality control) and QA (quality assurance) procedures are also independently followed to ensure the highest quality of each delivered coupling.

Shengnuo bio PRODUCT

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About Shengnuo

Chengdu Shengnuo Biotechnology Co., Ltd. has "Chengdu polypeptide drug engineering technology research center" in Chengdu, mainly engaged in polypeptide, polypeptide drug and beauty peptide research. Our zero defect has passed the FDA certification, and now it has become the first-class professional peptide drug and product development, technology transfer, technical service and peptide drug industry in the scale production and export of China's parks.