1. Peptide's past life and present life

2. Peptide is a kind of compound whose molecular structure is between amino acid and protein.

3. Effect of peptide on skin

4. The promoter of collagen

5. Smearable botulinum toxin

6. It is used in all high-end cosmetics.

The fairies who often read my articles know that I am an ingredient Party of red fruits. The most direct and effective way to know whether the effect of skin care products is good is to look at ingredients. For example, the moisturizing hyaluronic acid, whitening vitamin C and niacinamide are all familiar to us. So, who can occupy the C position among many ingredients? Today, we will learn about the new high-tech ingredient peptide emerging in the field of skin care in recent years.

In recent years, oligopeptides, polypeptides and peptides are widely used in skin care products, and are used by many pharmaceutical brands and international first-line brands. World famous cosmetics brands such as Estee Lauder, mystery of sea blue, and leponey have also launched skin care products containing peptides.

So, is "peptide" a secret product of beauty or a marketing gimmick made by branding? Today, we talk about the skin care efficacy of peptides through the 3 peptide components in the anti wrinkle cream.

Peptide's past life and present life

Weierxiao, the originator of cytopathology and a German medical expert, pointed out that "starting from the source of living cells, going deep into the molecular structure of cells, all diseases come from the change of cells."

From the biological point of view, the nutrients that make up the cells are mainly water, inorganic salt, fat, protein and other trace organic matters. Water accounts for 85% - 90%, protein accounts for 7% - 10%, and other nutrients account for about 4% - 6.5%. It is not difficult to find that protein accounts for more than half of the body's dry matter and is the most important nutrient in cells. Engels also asserted that "there is no life without protein."

In 1838, grant, a Dutch scientist, discovered protein, which made a great contribution to human health. Since then, proteins are closely related to cells, life and health. However, in the process of continuous in-depth research, scientists found that protein can not be directly absorbed and utilized by the human body, but can be decomposed into a single amino acid in the body and a part of the short chain is absorbed by the human body. The single amino acid can not be directly used. It needs to be linked into a short chain by several amino acids before it can be used by the human body. This short chain is a peptide.

In 1902, British scientists Bellis and Starling first discovered peptide substances in human body. Because of their profound influence, the Nobel Committee awarded them the highest prize: the Nobel Prize in physiology.

With more and more in-depth research, many functions of peptides have been confirmed. Peptide is an important substance related to many cell functions in human body. Peptides can synthesize cells and regulate their functional activities. Peptides act as neurotransmitters in the human body to transmit information. Peptide can be used as a means of transport in the human body to transport various nutrients, vitamins, biotin, calcium and trace elements beneficial to the human body to various cells, organs and tissues. Peptide is an important physiological regulator of human body. It can comprehensively regulate human physiological function, enhance and play human physiological activity. It has important biological function. Peptide plays an irreplaceable role in human cell activity, function and existence.

Relationship among amino acids, oligopeptides, polypeptides and proteins

Peptide is a kind of compound whose molecular structure is between amino acid and protein.

Although protein is a very important substance in human body, it is usually a very short and small structure that TA can really work, or carry out signal transmission and exchange with other proteins. It's like buying a huge durian home, but only one throw of it can be eaten.

The same is true of protein. If the structure is cracked in a certain way, and the redundant parts are removed, all that remains is the peptides that play the core role. These peptides have become the star ingredients of today's skin care industry. Of course, the price is also very expensive.

Amino acids are the smallest component of proteins. An amino acid molecule is called an amino acid. When two amino acid molecules are dehydrated, condensed and combined together, they are two peptides, and so on. They contain four amino acids, which are called four peptides; nine amino acids, which are called nine peptides; peptides with less than 10 amino acids are called oligopeptides, and peptides with more amino acids are called multi peptides, and proteins with more than 50 amino acids. At present, there is no uniform definition about the number of amino acids in oligopeptides, polypeptides and proteins. However, because of the different varieties of amino acids, there are different kinds of peptides, such as Ersheng peptide and Sansheng peptide. In short, amino acids make up peptides, peptides make up proteins.

Because our skin is a very dense structure, its main function is defense, not absorption. Therefore, an active ingredient wants to penetrate the cuticle, which is related to its hydrophilicity, molecular weight, three-dimensional structure, etc. The molecular weight of polypeptide itself will be relatively large (more than 500 daltons), and there are hydrophilic groups, so the skin cuticle is refused to enter.

So smart scientists have made structural modifications on polypeptides, and added palmitic acid or other lipophilic groups to make polypeptides more skin friendly. So the name of peptide usually consists of modifier amino acid number suffix number. That's why most polypeptides we see are called palmitoyl XX peptide or acetyl XX peptide. Children who love learning can refer to the comparison between the acetyl six peptide -8 and palmitic three peptide -5 in the inverse zero essence.

Effect of peptide on skin

Peptide was initially used in the products directly by some European and American cosmetics. Its mechanism is similar to that of protein. It can promote the proliferation of collagen, elastic fiber and hyaluronic acid, improve the water content of skin, increase the thickness of skin and reduce fine lines.

Moisturizing: peptide is an important part of natural moisturizing factor, which contains a large number of hydrophilic genes (amino, hydroxy, carboxyl) on the surface of molecular three-dimensional structure, with strong water locking property.

Nutrition: the peptide has strong penetration to the skin, can combine with the skin epithelium through the cuticle, participate in and improve the metabolism of the skin cells, enhance the collagen activity in the skin, maintain the water and fiber structure integrity of the cuticle, provide nutrition for the cells, and achieve the effect of nourishing the skin.

Anti aging: the production of wrinkles is related to the natural loss of collagen. Peptides can directly penetrate into the dermis to supplement the lost collagen, restructure the skin fiber structure, restore the skin elasticity, delay cell aging, and make the skin soft and smooth.

Whitening: human skin color is mainly determined by melanin in epidermal cells. The peptide also contains the factor of desalt pigment, which not only has the dual effects of preventing and desalt, but also has the characteristics of whitening skin without rebound.

Repair: peptide can directly penetrate into the bottom of the skin, directly repair the denatured cells, remove free radicals, assist the cells to produce collagen, and reorganize the skin fiber tissue.

Due to the different kinds of amino acids, the main functions of different peptides are also different. Let me briefly introduce the main functions of three kinds of peptides: palmitoyl tripeptide-5, acetylhexapeptide-8 and dipeptide diaminobutyrylbenzamide diacetate.

The promoter of collagen

Palmitoyl tripeptide-5, with its special structure, can "wake up" the cytokine TGF - β, let it not be lazy, get up to work quickly, increase horsepower to produce collagen, inhibit the activity of MMP (matrix metalloproteinase), protect the degradation of collagen, enhance cell activity, improve skin moisture content, and enhance skin luster. Many famous cosmetic brands abroad (such as Estee Lauder, Chanel, etc.) mostly contain palmitoyl tripeptide-5.

Smearable botulinum toxin

Botulinum toxin injection is a kind of common medical treatment for ladies, because botulinum toxin can block the release of neurotransmitters, relax muscles, and many false wrinkles will soon disappear. But after all, botulinum toxin is a bit fierce, and it's easy to suffer from facial paralysis if you don't fight well, so it produces various peptides with the action of botulinum toxin.

The famous acetylhexapeptide-8 and dipeptide diaminobutyrylbenzamide diacetate are peptides that play this role. They can block the release of neurotransmitters in facial muscles and have a significant anti-aging effect.

Acetylhexapeptide-8 is a kind of neurotransmitter blocking peptide, similar to the mechanism of botulinum toxin. By inhibiting acetylcholine, it can locally block the transmission of muscle contraction signals, relax the facial muscles, smooth the wrinkles, especially the expression lines. So to speak,

Acetylhexapeptide-8 is a shining new star in the field of cosmetic science. It can lighten the depth of wrinkles and inhibit the contraction of expressional muscles, especially near the eyes and forehead. It is comparable to Botox, but it is safer. It has become a popular wrinkle removing material in the world,

It is used in all high-end cosmetics.

Like Estee Lauder's "wire carving essence" that has been burning for a long time, it is known that it can be all-around and pulled tightly. It is luxuriously adding acetyl six peptide -8.

Dipeptide diaminobutyrylbenzamide diacetate is a synthetic peptide simulating snake venom. Its effect can reach to the muscle bottom, simulate the characteristics of nerve paralysis and muscle contraction after snake venom invades the human body, effectively block the signal transmission of muscle contraction, quickly smooth all kinds of expression lines, static lines and fine lines, and smooth the skin. There is a high-end medical beauty brand, filoga, which adds this ingredient to her eye cream.

Peptide is a very large family. In addition to the 3 peptides contained in the anti zero Wrinkle Essence, there are three peptide -33, palmitic five peptide -4 and so on. Although the name and efficacy are different, all peptides have one thing in common: the price is not cheap.

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About Shengnuo

Chengdu Shengnuo Biotechnology Co., Ltd. has "Chengdu polypeptide drug engineering technology research center" in Chengdu, mainly engaged in polypeptide, polypeptide drug and beauty peptide research. Our zero defect has passed the FDA certification, and now it has become the first-class professional peptide drug and product development, technology transfer, technical service and peptide drug industry in the scale production and export of China's parks.